Seth Wiley joined NREL at the beginning of 2023 as a postdoctoral researcher in Carolyn Lubner’s group studying coordination effects on cofactors in the mechanism of electron bifurcation in Pyrococcus furiosus NADH-dependent ferredoxin-NADP+ oxidoreductase I (NfnSL). Before NREL, Wiley worked at Emory University as a postdoctoral researcher in the lab of R. Brian Dyer studying the chemical and physical framework for how [FeFe] hydrogenases rapidly and reversibly convert protons and electrons into hydrogen under mild conditions. To study these quick hydrogenases, Wiley employed CdSe-based nanocrystalline semiconductors in conjunction with various spectroscopic techniques such as time-resolved infrared spectroscopy, cryogenic infrared spectroscopy, and UV-visible spectroscopy. Wiley received his Ph.D. in chemical biology at the University of Michigan in 2020 researching the underlying reaction mechanism of carbon incorporation by Acetyl-CoA Synthase (ACS) from Moorella thermoacetica under the mentorship of Stephen W. Ragsdale. In his time in the Ragsdale lab, Wiley worked extensively with various spectroscopic methods, focusing primarily on electron paramagnetic resonance (EPR), as well as anoxic laboratory techniques and protein purification.
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Research Interests
Bioinorganic chemistry
Biochemistry
Anaerobic enzymology
Infrared and visible spectroscopy
Electron transfer and bifurcation
Redox chemistry
Transient absorbance
Electrochemistry
EPR
Education
Ph.D., Chemical Biology, University of Michigan, 2020
B.S., Biochemistry, University of Kansas, 2014
Professional Experience
Postdoctoral Researcher, National Renewable Energy Laboratory (2023–Present)
Postdoctoral Research Fellow, R. Brian Dyer Laboratory, Emory University (2020–2023)
Graduate Student Research Assistant, Stephen W. Ragsdale Laboratory, University of Michigan (2016–2020)
Associations and Memberships
Member, American Chemical Society
Member, International Chemical Biology Society
Member, American Association for the Advancement of Science
Featured Work
Publications
Time-Resolved Infrared Spectroscopy Reveals the pH-Independence of the First Electron Transfer Step in the [FeFe] Hydrogenase Catalytic Cycle, The Journal of Physical Chemistry Letters (2022)
13C Electron Nuclear Double Resonance Spectroscopy Shows Acetyl-CoA Synthase Binds Two Substrate CO in Multiple Binding Modes and Reveals the Importance of a CO-Binding “Alcove,” Journal of the American Chemical Society (2020)
Production and Properties of Enzymes that Activate and Produce Carbon Monoxide, Methods in Enzymology (2018)
Presentations
Structural Rearrangements and Chemical Coupling Drive the Nickel-Based Organometallic Enzymology of Anaerobic CO2 and CO Fixation in Acetyl-CoA Synthase (ACS), The International Conference on Biological Inorganic Chemistry 19 (2019)
Awards and Honors
Graduate Assistance in Areas of National Need Fellow (2015–2017)
Life Sciences Institute Summer Fellowship (2015)
Phi Beta Kappa, ΦΒΚ (2013)
University of Kansas Slavic Department Honors for Advanced and Intermediate Russian (2010–2011)
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